Myeloid cells in metastasis-prone liver microenvironment
As the major cell type accumulated in the liver, myeloid cells play a key role in promoting cancer metastasis. Due to the plasticity and heterogenicity, how to effectively and specifically targeting myeloid cells in liver microenvironment remains underestimated. Thus, we would like to delineate the molecular features and functional significance of myeloid cell subsets in the metastasis-prone liver microenvironment, aiming at identifying myeloid-cell targeting therapies in the prevention and treatment for metastasis liver cancers.
Metabolic regulations of
hepatic T cells
The differentiation and function of T cells are reported to be controlled by different metabolic pathways. The liver is the central organ for fatty acid metabolism and dysregulations in lipid metabolism contribute to the development of chronic liver diseases and liver cancers. We would like to understand how these lipid metabolic pathways regulate hepatic T cell differentiation and functions to support cancer immune escape.
The nervous system has been well-documented in regulating immune responses in homeostasis and different diseases, including cancer. We would like to explore the potential functions of the nerve system on tumor progression and metastasis, and their immune regulatory mechanisms.
Neuro-immune axis in gastrointestinal cancers